RESYST
RIASSUNTO
Questo progetto affronta una delle principali questioni che interessano attualmente l’allevamento del bestiame: come il cambiamento climatico influisce sulla salute e sulle prestazioni delle vacche da latte. Il progetto si basa su un approccio di biologia dei sistemi, utilizzando le scienze omiche (metabolomica e trascrittomica) per studiare le basi molecolari della tolleranza allo stress da caldo nei bovini da latte. I campioni vengono raccolti in condizioni di campo, confrontando le razze Brown Swiss e Holstein allevate nella stessa azienda. Le vescicole extracellulari ottenute da sangue e latte sono caratterizzate per identificare diversi potenziali biomarcatori. La funzione biologica delle vescicole extracellulari viene successivamente validata in studi ex vivo e in vitro, con l’obiettivo di valutare gli effetti sui tessuti che svolgono un ruolo chiave nell’efficienza e nel benessere dei ruminanti da latte (ghiandola mammaria, intestino, cellule del sistema immunitario). I risultati degli studi saranno integrati e analizzati per identificare associazioni significative di marcatori con risposte allo stress da caldo con indicatori clinici, fisiologici e di produzione già noti. Poiché il progetto affronta un argomento ad alto impatto sulla produzione zootecnica e sulla sostenibilità, il progetto mira a coinvolgere tutte le parti interessate (agricoltori, associazioni di allevatori, associazioni di scienze animali, aziende che commercializzano sistemi di raffrescamento, aziende lattiero-casearie…) per un’efficace e rapido trasferimento delle conoscenze scientifiche alla fase di applicazione sul campo.
Codice Identificativo: PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE Bando 2022 Prot. 2022MPWFET CUP J53D23010270006
Costo totale del progetto: 314.596,00€
Costo totale DAFNE: 167.528,00 €
Ruolo DAFNE: Principal Investigator
Responsabile Scientifico DAFNE: Prof. Umberto Bernabucci
Email: bernab@unitus.it
Data inizio: 03/07/2023
Data fine: 02/07/2025
LINK
https://www.unitus.it/ricerca/progetti-di-ricerca/progetti-prin-2022/
PARTNERNARIATO
Department of Veterinary Medicine and Animal Sciences (DIVAS) of the University of Milan
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