XXXVII CICLO | De Marchi Elisa

Elisa De Marchi is a PhD student with a background in organic chemistry. Experienced in research, data analysis, and project management. Her education and laboratory experiences have enabled her the skill to use a variety of laboratory equipment, including nuclear magnetic resonance (NMR), mass spectrometer (MS), high-performance liquid chromatography (HPLC), gas chromatography (GC), infrared spectroscopy (IR), UV/Vis spectrophotometer, and other organic synthesis tools.

It is well acknowledged that there is an increasing need for ecologically friendly procedures in the chemical and pharmaceutical industries. To achieve this goal, the Green Chemistry movement was founded in 1990, and catalysis has become a key technique for greening chemistry. Catalysis can increase the reaction’s selectivity, simultaneously decreasing or eliminating the requirement for downstream processing, thus resulting in the formation of a limited number of waste products. In this context, singlet oxygen (1O2) has attracted the interest of researchers. Singlet oxygen can react with simple organic molecules, with complex biological molecules, and with cellular components, with high efficacy and rate constants. These reactions are archetypical green chemistry processes since they require a limited number of ingredients: substrate, visible light, air and dye antenna. In addition, singlet oxygen may be combined with enzymes in order to improve the sustainability of the overall process. By understanding the reactivity of singlet oxygen, it is possible to develop a powerful multipurpose tool for the synthesis of bioactive compounds. We investigate the use of singlet oxygen in photocatalytic and photochemoenzymatic procedures with the aim of developing eco-sustainable approaches for the synthesis of biologically active compounds starting from privileged natural scaffolds.

• Arnodo, D., De Nardi, F., Parisotto, S., De Nardo, E., Cananà, S., Salvatico, F., De Marchi, E., Scarpi, D., Blangetti, M., Occhiato, E. G., & Prandi, C. (2023). Asymmetric reduction of cyclic imines by Imine reductase enzymes in Non‐Conventional solvents. ChemSusChem. 

• Zippilli, C., Filippi, S., Cesarini, S., Bizzarri, B. M., Conigliaro, P., De Marchi, E., Botta, L., & Saladino, R. (2023). Synthesis of artesunic Acid–Coumarin hybrids as potential antimelanoma agents. ACS Medicinal Chemistry Letters, 14(5), 599–605. 

• De Marchi, E., Botta, L., Bizzarri, B. M., & Saladino, R. (2022). A green Blue LED-Driven Two-Liquid-Phase One-Pot procedure for the synthesis of Estrogen-Related quinol prodrugs. Molecules, 27(24), 8961. 

• De Marchi, E., Arnodo, D., Maffeis, E., Scarpi, D., Prandi, C., & Occhiato, E. G. (2021). Enantiodivergent Synthesis of Halofuginone by Candida antarctica Lipase B (CAL-B)-Catalyzed Kinetic Resolution in Cyclopentyl Methyl Ether (CPME). SynOpen, 05(02), 145–151.