TarHegh

Targeting Hedgehog pathway: virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors

Acronimo: TarHegh

ABSTRACT 

In recent years, the Hedgehog (Hh) pathway has emerged as the most promising target for the development of anticancer drugs. In the past, a variety of Smo antagonists have been developed but their clinical use has failed due to different issues such as pharmacokinetics and the emergence of drug resistance. For this reason, the development of new effective Hh inhibitors is needed. The present project is devoted to the modulation of the Hh signaling pathway by new chemical entities (NCE) designed by coupling synthetic feasibility criteria with pharmacophoric and steric features. In particular, this proposal would lead to selection of new classes of compounds by a ligand-based molecular modeling or structure-based approaches and their synthesis through innovative and sustainable chemical processes, a priority of modern chemistry. Furthermore, the study will be aimed at developing of suitable delivery technologies to provide a viable alternative for cancer therapy.

Identification Code: CUP J84I17000020001

Total project cost: 1.197.192,69 Euro

Total cost DAFNE: 103.659,8 Euro

DAFNE Role: Responsabile di Unità di Ricerca
Scientific Supervisor DAFNE: Prof. Roberta Bernini 

Email: roberta.bernini@unitus.it

Start date: 29/10/2019 

End date: 29/10/2023

LINK 

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PARTNERSHIP

• Università degli Studi di Roma La Sapienza 
• Università degli Studi di Bologna 
• Università degli Studi di Milano 
• Università degli Studi di Padova 
• Università degli Studi della Tuscia, DAFNE
• Centro Nazionale delle Ricerche 

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