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Declino cognitivo, perdita di funzionalità muscolare e alterazioni del microbiota intestinale associati all’invecchiamento: effetti protettivi dell’idrossitirosolo, componente dell’olio di oliva e di estratti da sottoprodotti oleari
Acronimo: OLIVIA (Olio anti neuromuscoLo InVecchIAmento)
ABSTRACT
Cognitive decline, loss of muscle mass and strength, and alterations in the composition of the gut microbiota are chronic pathological traits related to aging that can be prevented or delayed with the Mediterranean diet. Hydroxytyrosol (HTyr) is a phenolic compound found in extra virgin olive oil that may exert a protective effect in several chronic age-associated diseases due to its antioxidant, anti-inflammatory and neuroprotective properties. Recent results published by the research team have shown that HTyr has pro-neurogenic activity, stimulating the proliferation of stem and progenitor cells in neurogenic niches of the brain in aged mice and increasing the survival of newly produced neurons. This project aims to study in an animal model of aging the potential beneficial effects of oral treatment with HTyr and HTyr-enriched extracts obtained from the by-products of oil production through innovative and sustainable technologies.
In particular, the project is divided into the following WPs:
WP1. Production of HTyr and HTyr-enriched extracts.
WP2. Effects of HTyr and enriched extracts on neurogenesis and cognitive abilities of aged mice.
WP3. Effects of HTyr and enriched extracts on skeletal muscle function in aged mice.
WP4. Effects of HTyr and enriched extracts on gut microbiota composition of aged mice.
Identification Code: CUP: B55F21003560008
Total project cost: 150.000 Euro
Total cost DAFNE: 37.502 Euro
DAFNE Role: Responsabile di Unità di Ricerca
Scientific Supervisor DAFNE: Prof. Roberta Bernini
Email: roberta.bernini@unitus.it
Start date: 21/07/2021
End date: 22/07/2024
LINK
https://ec.europa.eu/regional_policy/it/funding/erdf/2014-2020
http://www.lazioinnova.it/bandi-post/progetti-gruppi-ricerca-2020
https://www.unitus.it/ricerca/progetti-di-ricerca/progetto-olivia/
PARTNERSHIP
Università degli Studi della Tuscia di Viterbo, Dipartimento di Scienze Agrarie e Forestali (DAFNE): Prof.ssa Roberta Bernini; Dipartimento di Scienze Ecologiche e Biologiche (DEB): Prof.ssa Carla Caruso, Dott.ssa Laura Bertini
Consiglio Nazionale delle Ricerche, Istituto di Biochimica e Biologia Cellulare (CNR-IBBC), Monterotondo (Roma): Dott. Felice Tirone (Coordinatore del progetto), Dott.ssa Laura Micheli, Dott.ssa Maurizia Caruso
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