{"id":69938,"date":"2024-09-17T09:54:04","date_gmt":"2024-09-17T07:54:04","guid":{"rendered":"https:\/\/www.unitus.it\/?page_id=69938"},"modified":"2024-09-17T10:01:05","modified_gmt":"2024-09-17T08:01:05","slug":"tarhegh","status":"publish","type":"page","link":"https:\/\/www.unitus.it\/en\/research\/progetti-di-ricerca\/tarhegh\/","title":{"rendered":"TarHegh"},"content":{"rendered":"<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-66117\" src=\"https:\/\/www.unitus.it\/wp-content\/uploads\/2024\/08\/Clipboard_08-26-2024_20.jpg\" alt=\"\" width=\"177\" height=\"177\" \/><\/h3>\n<h3><b>Targeting Hedgehog pathway: virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors<\/b><\/h3>\n<p><b>Acronimo: TarHegh<\/b><\/p>\n<p>&nbsp;<\/p>\n<p><b>ABSTRACT\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400;\">In recent years, the Hedgehog (Hh) pathway has emerged as the most promising target for the development of anticancer drugs. In the past, a variety of Smo antagonists have been developed but their clinical use has failed due to different issues such as pharmacokinetics and the emergence of drug resistance. For this reason, the development of new effective Hh inhibitors is needed. The present project is devoted to the modulation of the Hh signaling pathway by new chemical entities (NCE) designed by coupling synthetic feasibility criteria with pharmacophoric and steric features. In particular, this proposal would lead to selection of new classes of compounds by a ligand-based molecular modeling or structure-based approaches and their synthesis through innovative and sustainable chemical processes, a priority of modern chemistry. Furthermore, the study will be aimed at developing of suitable delivery technologies to provide a viable alternative for cancer therapy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Identification Code: CUP J84I17000020001<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Total project cost: 1.197.192,69 Euro<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Total cost DAFNE: 103.659,8 Euro<\/span><\/p>\n<p><span style=\"font-weight: 400;\">DAFNE Role: Responsabile di Unit\u00e0 di Ricerca<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Scientific Supervisor DAFNE: Prof. Roberta Bernini\u00a0<\/span><\/p>\n<p>Email:<a href=\"mailto:roberta.bernini@unitus.it\"><span style=\"font-weight: 400;\"> roberta.bernini@unitus.it<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Start date: 29\/10\/2019\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">End date: 29\/10\/2023<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>LINK\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400;\">&#8211;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">PARTNERSHIP<\/span><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Universit\u00e0 degli Studi di Roma La Sapienza\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Universit\u00e0 degli Studi di Bologna\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Universit\u00e0 degli Studi di Milano\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Universit\u00e0 degli Studi di Padova\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Universit\u00e0 degli Studi della Tuscia, DAFNE<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Centro Nazionale delle Ricerche\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-65820\" src=\"https:\/\/www.unitus.it\/wp-content\/uploads\/2024\/08\/Clipboard_08-26-2024_09.jpg\" alt=\"\" width=\"95\" height=\"63\" \/>\u00a0 <a href=\"https:\/\/european-union.europa.eu\/select-language?destination=\/node\/1\"><span style=\"font-weight: 400;\">Your gateway to the EU, News, Highlights<\/span><\/a><span style=\"font-weight: 400;\"> | European Union<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Discover how the EU functions, its principles, priorities; find out about its history and member countries; learn about its legal basis and your EU rights.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><a href=\"http:\/\/www.europa.eu\"><span style=\"font-weight: 400;\">www.europa.eu<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Targeting Hedgehog pathway: virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors Acronimo: TarHegh &nbsp; [&hellip;]<\/p>\n","protected":false},"author":28,"featured_media":0,"parent":5652,"menu_order":78,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"ppma_author":[89],"class_list":["post-69938","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TarHegh - Unitus<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unitus.it\/en\/research\/progetti-di-ricerca\/tarhegh\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TarHegh - Unitus\" \/>\n<meta property=\"og:description\" content=\"Targeting Hedgehog pathway: virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors Acronimo: TarHegh &nbsp; 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